Chasing Chimeras – The elusive stable chondrogenic phenotype

Valeria Graceffa, Claire Vinatier, Jerome Guicheux, Martin Stoddart, Mauro Alini,Dimitrios I. Zeugolis

Biomaterials Volume 192, February 2019, Pages 199-225 - Download full text

PiT1/Slc20a1 is required for endoplasmic reticulum homeostasis, chondrocyte survival and skeletal development

Couasnay G, Bon N, Devignes CS, Sourice S, Bianchi A, Véziers J, Weiss P, Elefteriou F, Provot S, Guicheux J, Beck-Cormier S, Beck L

J Bone Miner Res. 2018 Oct 22 - Download full text

Proceedings of the signature series symposium "cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," international society for cellular therapies, montreal, canada, may 2, 2018

Piuzzi NS, Dominici M, Long M, Pascual-Garrido C, Rodeo S, Huard J, Guicheux J, McFarland R, Goodrich LR, Maddens S, Robey PG, Bauer TW, Barrett J, Barry F, Karli D, Chu CR, Weiss DJ, Martin I, Jorgensen C, Muschler GF

Cytotherapy. 2018 Oct 10. - Download full text

Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering

Buchtová N, D'Orlando A, Judeinstein P, Chauvet O, Weiss P, Le Bideau J

Carbohydr Polym. 2018 Dec 15;202:404-408 - Download full text

Post-doc position on notochordal differentiation and stem cell-based therapy for intervertebral disc degeneration (starting from March 2019)

image offre d'emploi

A 24 months-postdoctoral position (funded by H2020 European research project iPSPINE,Coord. Marianna Tryfonidou, The Netherlands) working on iPS differentiation and regenerative medicine is available, starting from March 2019 in our research lab. Human iPSC maintenance and production will be performed in close collaboration with the DeviPS core facility (SFR François Bonamy, INSERM UMS 016, Nantes University), which is coordinated by the Dr. Laurent David (a specialist of somatic cell reprogramming, MCU-PH and coordinator of the platform). Selected candidate will work under the supervision of Dr Anne Camus, leader of “Stem Cells and Axial Skeleton Development” project in the team “skeletal physiopathology and joint regenerative medicine” headed by Jerome Guicheux. Applicants are invited to send a CV with skills and complete list of publications, a cover letter including a brief statement of past scientific experiences, achievements, name and email address of 2-3 references to Anne CAMUS, Jerome GUICHEUX and Laurent DAVID. Our job offer can be downloaded here !


H2020An additional Horizon 2020 European research grant for INSERM UMR 1229-RMeS towards treating chronic back pain

In 2016, the European commission invested 5.5 millions Euros in the RESPINE project to clinically address whether bone marrow-derived mesenchymal stromal cells may help solve low back pain that affects hundreds of millions of patients worldwide. The double blind phase 2b RESPINE clinical trial (P.I. Christian Jorgensen, Montpellier University Hospital; EudraCT 2017-002092-25) is now recruiting more than 100 patients in France and European countries. Jerome Guicheux (Nantes scientific coordinator, STEP Team, INSERM UMR 1229-RMeS) is a task leader in this project in charge of developing cutting-edge potency assays for the preclinical evaluation of the regenerative potential of stem cells (Cécile Boyer). Fifteen patients will be recruited at the Nantes University Hospital in the department of neurotraumatology and neurosurgery (Eric Bord). After the successful funding of RESPINE, the STEP team of the INSERM UMRS 1229-RMeS is now pleased to announce the recent selection of the H2020 iPSpine project by the European commission. iPSpine will receive an overall grant of 15 M€. This large European consortium will gather 20 international partners and will be coordinated by Marianna Tryfonidou (Utrecht University, The Netherlands). This project will officially be launched in February 2019 and it will deal with the development of advanced therapy medicinal products based on the use of biomaterials and induced-pluripotent stem cells (iPSC) towards solving intervertebral disc (IVD) degeneration. Jerome Guicheux is the scientific coordinator of iPSpine workpackage (WP) 1 “iPSC development, differentiation and technologies” that gathers 7 international partners and focus on discovering innovative culture protocols for the generation of IVD cells derived from human iPSC (Anne Camus). In collaboration with the ONIRIS-national veterinary school of Nantes, the STEP team will also participate in WPs 3 and 6 respectively dedicated to (i) in vitro 3D cell culture (Catherine Le Visage, RMeS) and (ii) the first canine clinical trial related to the efficacy of the intradiscal injection of iPSC-derived regenerative cells in the treatment of low back pain (Marion Fusellier & Johann Clouet). RMeS will receive a global support of about 1.3 million Euros and will recruit 1 post-doc, 2 research assistants and 1 clinical assistant.

FRMFRM announcement

The STEP team is pleased to announce the funding of Vianney Delplace’s position by the Fondation pour la Recherche Médicale (FRM) for 3 years. Using his expertise in hydrogel design, Vianney Delplace will develop innovative intra-articular cell therapies for the treatment of osteoarthritis, under the supervision of Catherine Le Visage and Jérôme Guicheux. In collaboration with Arnaud Tessier from the CEISAM laboratory (UMR CNRS 6230, Nantes), a new class of self-healing hydrogels will be designed to best mimic the biomechanical properties of native cartilages and deliver anti-inflammatory factor secreting stem cells.  

ANRANR Research Grants

A triple success for the INSERM-Nantes University-ONIRIS UMRS 1229-RMeS laboratory at the 2018 call for proposal of the French national research Agency (ANR) as coordinator. The STEP team is pleased to announce the funding of two novel projects, PPAROA and KLOTHOA. PPAROA is an ANR collaborative research project (PRC) that will be coordinated by Jerome Guicheux (INSERM UMRS 1229-RMeS). PPAROA will aim to define the role of the nuclear Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta in the anti-osteoarthritic and immunomodulatory properties of adult mesenchymal stem cells. In partnership with the Christian Jorgensen’s Laboratory (INSERM UMRS 1183-IRMB, University of Montpellier), the PPAROA project will be supported by the ANR for 4 years. KLOTHOA is an ANR young researchers (JC/JC) project that will be coordinated by Claire Vinatier (INSERM UMRS 1229-RMeS). KLOTHOA will aim to define the role of the anti-aging protein Klotho in the onset of osteoarthritis and whether modulating the expression of Klotho by adeno-associated virus-mediated gene therapy may help identify novel anti-osteoarthritic treatments. The KLOTHOA project will be supported by the ANR for 3 years. The REGOS team is also pleased to announce the funding of an industrial collaborative research project. The IXBONE project, coordinated by Pierre Weiss (INSERM UMRS 1229-RMeS) will aim to define new bone regeneration strategies for the treatment of mandibular osteoradionecrosis using mesenchymal stem cells and innovative biomaterials. In partnership with the French Institute for Radiological Protection and Nuclear Safety (IRSN, Fontenay aux Roses, Noëlle Mathieu) and the French Organ, Tissue, Regeneration, Repair and Replacement company (OTR3, Paris, Denis Barritault), the IXBONE project will be supported by the ANR for 4 years.  

Fondation AvenirFondation de l'Avenir Research Grant

The STEP team is pleased to announce the funding of the CAPSTEM project by the Fondation de l’Avenir pour la Recherche Médicale Appliquée. CAPSTEM will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Anne Des Rieux from the Louvain Drug Research Institute (LDRI, Louvain, Belgium). CAPSTEM will aim to determine whether encapsulating mesenchymal stem cells in hydrogel-based microcapsules may help exploit their anti-osteoarthritic properties. The CAPSTEM project is funded for 2 years and will be conducted in the framework of Audrey Smith’s PhD Thesis.

Workshops & symposia

Symposium "RNA interference to promote tissue regeneration" during 5th Termis World Congress (Session 68)

Organized by Sing Yian CHEW,Singapour and V. Geoffroy
on September 7th, 2018
Kyoto International Conference Center, Kyoto, Japan - Sept. 4-7, 2018



Laurent DavidLaurent David, PhD

Hydrogels physiques de chitosane pour l'ingénierie tissulaire in vivo et in vitro

University Claude Bernard Lyon
November 26th, 2018, 14h30 - Amphi Ricordeau (Dental Faculty)


Elise LepeltierElise Lepeltier, PhD

Décoration en surface de nanoparticules et auto-assemblages: atteindre au plus près la cible thérapeutique

Angers University
September 18th, 2018, 11h - Meeting Room RMeS


New members

Fabien NativelFabien Nativel

Fabien is a PhD student.
He will work on mesenchymal stem cell encapsulation in hydrogels for the treatment of osteoarthritis

He joined our unit on Nov. 5th 2018
His supervisors are Catherine Le Visage and Jérôme Guicheux

Brian Le MoalBrian Le Moal

Brian is a PhD student.
He will work on the development of nanoplatforms to vectorize biologic factors to treat intervertebral disc degeneration.

He joined our unit on Oct. 1st 2018
His supervisor is Johann Clouet

Anaïs DefoisAnaïs Defois

Anaïs is a PhD student.
She will work on the GenOA project : "Gene therapy for OsteoArthritis: controlled expression of anti-geronic factors"

She joined our unit on Oct. 1st 2018
Her supervisors are Y. Maugars and C. Vinatier

Francois lollFrançois Loll

François is an INSERM Engineer. He will work on BIO3 Platform (Biomaterials, Biohydrogels, Biomechanics facility) and, more particularly, on characterization of hydrogels. He will also be involved in implementing novel fabrication technologies, such as electrospinning and micromolding technologies.

He joined our unit on Oct. 1st 2018

PhD defense & HDR

Pauline ChichiriccoPhD Defense of Pauline Chichiricco

Pauline Chichiricco will defend her thesis on November 26, 2018, at 10.00 am (Amphi Ricordeau, Dental Faculty)

Interpenetrating polymer networks hydrogels of silanized hydroxypropylmethyl cellulose/methacrylated polysaccharides for biomedical applications

Directeur de thèse: P. Weiss - Co-directeurs : X. Struillou et C. Jérôme (Liège University)

Maude GluaisPhD Defense of Maude Gluais

Maude Gluais will defend her thesis on December 18, 2018, at 14.00 pm (Amphi Denis Escande, IRS-UN)

Mise au point et évaluation de biomatériaux électrospinés pour la régénération de l’Annulus fibrosus

Directeur de thèse: C. Le Visage- Co-directeurs : J. Guicheux et J. Clouet

Amadou TourePhD Defense of Amadou Toure

Amadou Toure will defend her thesis on December 19, 2018, at 9.30 am (Amphi Ricordeau, Dental Faculty)

Contribution au développement de substituts osseux auto-réticulants en ingénierie tissulaire osseuse maxillo-faciale

Directeur de thèse: P. Weiss - Co-directeur : B. Giumelli

Alexandra CloitrePhD Defense of Alexandra Cloitre

Alexandra Cloitre will defend her thesis on December 19, 2018, at 1.30 pm (Amphi Ricordeau, Dental Faculty)

La destruction osseuse parodontale : physiopathogénie et rôle des nouvelles interleukines

Directeur de thèse: P. Lesclous - Co-directeur : V. Geoffroy

And among other things...

General Assembly 2018
RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!