Biotechnology Advance
State of art and limitations in genetic engineering to induce stable chondrogenic phenotype

Graceffa V, Vinatier C, Guicheux J, Evans CH, Stoddart M, Alini M, Zeugolis DI

Biotechnol Adv. 2018 Jul 13 - Download full text

Clinical relevance of 3D gait analysis in patients with haemophilia

Fouasson-Chailloux A, Maugars Y, Vinatier C, Trossaert M, Menu P, Rannou F, Guicheux J, Dauty M

Haemophilia. 2018 Jul 10. - Download full text

A Cellulose/Laponite Interpenetrated Polymer Network (IPN) Hydrogel: Controllable Double-Network Structure with High Modulus

Fan Xie, Cécile Boyer, Victor Gaborit, Thierry Rouillon, Jérôme Guicheux, Jean-François Tassin, Valérie Geoffroy, Gildas Réthoré and Pierre Weiss

Polymers 2018, 10(6), 634 - Download full text

Application of millifluidics to encapsulate and support viable human mesenchymal stem cells in a polysaccharide hydrogel

Fabien Nativel, Denis Renard, Fahd Hached, Pierre-Gabriel Pinta, Cyril D'Arros, Pierre Weiss, Catherine Le Visage, Jérôme Guicheux, Aurélie Billon-Chabaud, Gael Grimandi

Int. J. Mol. Sci. 2018, 19(7), 1952 - Download full text


ANRANR Research Grants

A triple success for the INSERM-Nantes University-ONIRIS UMRS 1229-RMeS laboratory at the 2018 call for proposal of the French national research Agency (ANR) as coordinator. The STEP team is pleased to announce the funding of two novel projects, PPAROA and KLOTHOA. PPAROA is an ANR collaborative research project (PRC) that will be coordinated by Jerome Guicheux (INSERM UMRS 1229-RMeS). PPAROA will aim to define the role of the nuclear Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta in the anti-osteoarthritic and immunomodulatory properties of adult mesenchymal stem cells. In partnership with the Christian Jorgensen’s Laboratory (INSERM UMRS 1183-IRMB, University of Montpellier), the PPAROA project will be supported by the ANR for 4 years. KLOTHOA is an ANR young researchers (JC/JC) project that will be coordinated by Claire Vinatier (INSERM UMRS 1229-RMeS). KLOTHOA will aim to define the role of the anti-aging protein Klotho in the onset of osteoarthritis and whether modulating the expression of Klotho by adeno-associated virus-mediated gene therapy may help identify novel anti-osteoarthritic treatments. The KLOTHOA project will be supported by the ANR for 3 years. The REGOS team is also pleased to announce the funding of an industrial collaborative research project. The IXBONE project, coordinated by Pierre Weiss (INSERM UMRS 1229-RMeS) will aim to define new bone regeneration strategies for the treatment of mandibular osteoradionecrosis using mesenchymal stem cells and innovative biomaterials. In partnership with the French Institute for Radiological Protection and Nuclear Safety (IRSN, Fontenay aux Roses, Noëlle Mathieu) and the French Organ, Tissue, Regeneration, Repair and Replacement company (OTR3, Paris, Denis Barritault), the IXBONE project will be supported by the ANR for 4 years.  

Fondation AvenirFondation de l'Avenir Research Grant

The STEP team is pleased to announce the funding of the CAPSTEM project by the Fondation de l’Avenir pour la Recherche Médicale Appliquée. CAPSTEM will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Anne Des Rieux from the Louvain Drug Research Institute (LDRI, Louvain, Belgium). CAPSTEM will aim to determine whether encapsulating mesenchymal stem cells in hydrogel-based microcapsules may help exploit their anti-osteoarthritic properties. The CAPSTEM project is funded for 2 years and will be conducted in the framework of Audrey Smith’s PhD Thesis.

NexTNexT Initiative Research Grant

The STEP team is pleased to announce the funding of the SHELBY project by the NEXT initiative of the Nantes University (Internal Interdisciplinary Projects). SHELBY will be coordinated by Catherine Le Visage in collaboration with Claire Vinatier and Jerome Guicheux from RMeS laboratory, Denis Renard from the BIA laboratory (INRA UR 1268, Nantes) and Arnaud Tessier from the CEISAM laboratory (UMR CNRS 6230, Nantes). SHELBY will aim at developing a new generation of functionalized boronic acid hydrogels with self-healing properties and evaluating their ability to encapsulate mesenchymal stem cells and prevent osteoarthritis. The SHELBY project is funded for 1 year with possible extension up to 4 years and will be developed in the framework of Fabien Nativel’s PhD Thesis.

Workshops & symposia

Symposium "RNA interference to promote tissue regeneration" during 5th Termis World Congress (Session 68)

Organized by Sing Yian CHEW,Singapour and V. Geoffroy
on September 7th, 2018
Kyoto International Conference Center, Kyoto, Japan - Sept. 4-7, 2018



Elise LepeltierElise Lepeltier, PhD

Décoration en surface de nanoparticules et auto-assemblages: atteindre au plus près la cible thérapeutique

Angers University
September 18th, 2018, 11h - Meeting Room RMeS


Dr. Johnna TemenoffDr. Johnna Temenoff

GAG-based Biomaterials to Address Tissue Degeneration after Rotator Cuff Tendon Tears

Georgia Tech/Emory University
July 3rd, 2018, 14.00h - IRS UN - Amphi D. Escande


New members

Marianne LafontMarianne Lafont

Marianne is Engineer. She will work on ANR program GELIHPARBAL in collaboration with Jérome Sohier in Lyon. She will characterize new elastic hydrogels for muscle Tissue Engineering

She will join the REGOS team on Sept. 17 2018

Pierre GuihardPierre Guihard

Pierre Guihard (PhD) is associated-Professor at the school of dental medicine of Nantes university. His project is aimed at characterizing the coordinated role of Matrix Gla protein and PiT transporters in regulating bone homeostasis

He will join the STEP team on Sept. 1 2018

Gaël RochefortGaël Rochefort

Gaël (PhD-HDR) is Maturation Research Engineer from SATT Ouest Valorisation affected to RMeS. He will work on Cardiogel project in collaboration with Institut du Thorax

He will join the REGOS team on Sept. 3 2018

Vianney DELPLACEVianney Delplace

Vianney is post-doc
He will work on the development of injectable and self-healing hydrogels for the delivery of cells and/or molecules.

He will join the STEP team on Sept. 10 2018

PhD defense & HDR

Lara FigueiredoPhD Defense of Lara Figueiredo

Lara Figueiredo will defend her thesis on September 17, 2018, at 2.00 pm (Amphi Ricordeau, Dental Faculty)

3D biomimetic matrices to design in vitro stem cell niches

Pauline ChichiriccoPhD Defense of Pauline Chichiricco

Pauline Chichiricco will defend her thesis on November 26, 2018, at 10.00 am (Amphi Ricordeau, Dental Faculty)

Interpenetrating polymer networks hydrogels of silanized hydroxypropylmethyl cellulose/methacrylated polysaccharides for biomedical applications

Directeur de thèse: P. Weiss - Co-directeurs : X. Struillou et C. Jérôme (Liège University)

Alexandra CloitrePhD Defense of Alexandra Cloitre

Alexandra Cloitre will defend her thesis on December 19, 2018, at 1.30 pm (Amphi Ricordeau, Dental Faculty)

La destruction osseuse parodontale : physiopathogénie et rôle des nouvelles interleukines

Directeur de thèse: P. Lesclous - Co-directeur : V. Geoffroy

And among other things...

General Assembly 2018
RMeS General Assemby (Campus Gavy - St Nazaire) -
May 14th, 2018

Photo Fête de Noël
Christmas Party RMeS ! December 18th, 2017

Olympiades RMES

The 2nd Edition of the RMeS "Olympiades" has taken place on Sept. 18th, 2017. 4 teams have met in good spirits. Thanks to all the participants!